Publications | Hsing-Chen Tsai, M.D., Ph.D | National Taiwan University College of Medicine

Chen HY, Hsieh WC, Liu YC, Li HY, Liu PY, Hsu YT, Hsu SC, Luo AC, Kuo WC, Huang YJ , Liou GG, Lin MY, Ko CJ, Tsai HC, and Chang SJ. (2024) Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype. Nat Commun. 15, Article number: 2778

Chiu TY, Lo CH, Lin YH, Lai YD, Lin SS, Fang YT, Huang WS, Huang SY, Tsai PY, Yang FH, Chong WM, Wu YC, Tsai HC, Liu YW, Hsu CL, Liao JC and Wang WJ. (2023) INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control. Communications Biology September 05,volume 6, Article number: 911

Tien FM, Lu HH, Lin SY and Tsai HC. (2023) Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities. J Biomed Sci. 2023 Jan 10;30(1):3

Lin SY, Lu HH, Yu CJ, Huang YJ, Tong PI, Chen YW, Yang TY, Chen CY, Wei KL, Liao WY, Ho CC, Shih JY, Chen JS, Chiu YL, Chiu HM, Kuo SW and Tsai HC. (2021) Diagnostic and dynamic circulating methylated DNA markers for non-small-cell lung cancer. Respirology. 26: 39-39: Abstract O14-3.

Shih HM, Pan SY, Wu CJ, Chou YH, Chen CY, Chang FC, Chen YT, Chiang WC, Tsai HC, Chen YM, and Lin SL. (2021) Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells. J Biomed Sci. 2;28(1):73.

Hsieh WC, Lai EY, Liu YT, Wang YF, Tzeng YS, Lu C, Lai YJ, Huang HC, Huang JH, Ni HC, Tsai DY, Liang JJ, Liao CC, Lu YT, Jiang L, Liu MT, Wang JT, Chang SY, Chen CY, Tsai HC, Chang YM, Wernig G, Li CW, Lin KI, Lin YL, Tsai HK, Huang YT, and Chen SY. (2021) NK cell receptor and ligand composition influences the clearance of SARS-CoV-2. J Clin Invest. 131(21):e146408.

Chen SY, Huang CK, Peng HC, Tsai HC, Huang SY, Yu CJ, and Chien JY. (2021) Peak-Inspiratory-Flow-Rate Guided Inhalation Therapy Reduce Severe Exacerbation of COPD. Front. Pharmacol. 12: 704316

Weng RH, Lu HH, Lin CT, Fan CC, Lin RS, Huang TC, Lin SY, Huang YJ, Juan YH, Wu YC, Hung ZC, Liu C, Lin XH, Hsieh WC, Chiu TY, Liao JC, Chiu YL, Chen SY, Yu CJ, Tsai HC. (2021) Epigenetic modulation of immune synaptic-cytoskeletal networks potentiatesγδ T cell-mediated cytotoxicity in lung cancer. Nat Commun. 12(1): 2163

Lu HH, Lin SY, Weng RH, Juan YH, Chen YW , Hou HH, Hung ZC, Oswita GA, Huang YJ, Shih JY, Yu CJ, Tsai HC. (2020) Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma. EBioMedicine 57: 102846

Weng RH, Lin CT, Huang TC, Lu HH, Wu YC, Lin XH, Lin RS, Yu CJ and Tsai HC.(2019) DNA demethylating agents enhance susceptibility of lung cancer cells to γδ T cell-based immunotherapy via MHC-independent mechanisms. Cancer Res. 79(13 Suppl): Abstract nr 583.

Lu HH, Juan YH, Weng RH, Lin SY, Chen YW, Hou HH, Hung ZC, Huang YJ, Yang TY, Wu YC, Oswita GA, Shih JY, Tsai HCand Yu CJ. (2019) Fucosyltransferase 4-mediated aberrant glycosylation and cell signaling networks promote lung cancer metastasis.Cancer Res. 79(13 Suppl): Abstract nr 1111.

Tsai HC, Wu YC, Lin SY, Chen IY, Lee JH, Cheng KH, Wang PH, Ko HJ, Huang WC, Huang YJ, Wei KL, Yu CJ and Chiu YL. (2019)Epigenetic therapy restores polyfunctionality of malignant pleural effusion T-cells in patients with non-small cell lung cancer without downregulation of PD-1.Cancer Immunol Res. 7(2 Suppl): Abstract nr A221

Wu YC, Lin SY, Chen IY, Lee JH, Cheng KH, Ko HJ, Huang WC, Yu CJ, Chiu YL, and Tsai HC.(2018) Epigenetic therapy modulates polyfunctionality of tumor-reactive T cells in non-small cell lung cancer. Respirology 20: 23(Suppl. 2): 71-72

Lin SY, Chen YW, Yang TY, Wu YC, Oswita GA, Weng RH Roc, Lu HH, Lu HH, Tsai HC.(2018) Oncogenic and Immune Pathways Correlated with Molecular Prognostic Marker Sialyltransferase ST3GAL3 In Non-Small Cell Lung Cancer. Respirology 20: 23(Suppl. 2): 90–334

Chang TH, Tsai MF, Gow CH, Wu SG, Liu YN, Chang YL, Yu SL, Tsai HC, Lin SW, Chen YW, Kuo PY, Yang PC, Shih JY. (2017) Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. Cancer Lett 402:190-202

Cai Y*, Tsai HC*, Yen R-Y, Xia L, Zhang Y, Wang W, Baylin SB. (2017) Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Genome Res 27:533-544 *contributed equally

Calmon MF, Jeschke J, Zhang W, Dhir M, Siebenkas C, Herrera A, Tsai HC, O’Hagan HM, Pappou EP, Hooker CM, Fu T, Schuebel KE, Gabrielson E, Rahal P, Herman JG, Baylin SB, Ahuja N. (2015) Epigenetic Silencing of Neurofilament Genes Promotes an Aggressive Phenotype in Breast Cancer. Epigenetics 10(7):622-32

Easwaran H, Tsai HC, Baylin SB. (2014) Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell 54(5):716-27. [Review]

Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RW, Ahuja N, Brock M, Stearns V, Feller-Kopman D, Yarmus LB, Lin YC, Welm AL, Issa JP, Minn I, Matsui W, Jang YY, Sharkis SJ, Baylin SB, Zahnow CA. (2012) Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells. Cancer Cell 21(3):430-46.

Tsai HC, Baylin SB (2011) Cancer epigenetics: linking basic biology to clinical medicine. Cell Res. 21(3):502-17 [Review]

Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN (2010) A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene 29(17):2467-76

Ye Y, McDevitt MA, Guo M, Zhang W, Galm O, Gore SD, Karp JE, Maciejewski JP, Kowalski J, Tsai HL, Gondek LP, Tsai HC, Wang X, Hooker C, Smith BD, Carraway HE, Herman JG (2009) Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies. Cancer Res 69(21): 8482-8490

Yi JM*, Tsai HC*, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB (2008) Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors. Cancer Res 68(19): 8094-103 *contributed equally

Tsai HC, Liaw YS, Chen YJ, Gau CS, Yu CJ, Luh KT (2004) Management of Anti-tuberculosis Drug-related Hepatotoxicity: Comparison of the Fluoroquinolone-containing Regimen and Re- challenge with the Standard Regimen. Thoracic Medicine 19(6): 453-462

Tsai HC, Kuo PH, Yang PC (2003) Fever, Consciousness Disturbance, and Muscle Rigidity in a 68-Year-Old Man With Depressive Disorder. Chest 124:1598-1601

Lu JY, Chang CC, Tsai HC, Lin KH, Tsang YM, Huang KM (2001) Diabetic Ketoacidosis And Hypogonadotropic Hypogonadism In Association With Transfusional Hemochromatosis In A Man With Beta-thalassemia Major. Journal of the Formosan Medical Association 100: 492-6